Dr jan felix hoffmann biography
Felix Hoffmann
German chemist, creator of analgesic and heroin (–)
For other party named Felix Hoffmann, see Felix Hoffmann (disambiguation).
Felix Hoffman | |
|---|---|
| Born | 21 January |
| Died | 3 February () (aged&#;78) |
Felix Hoffmann (21 January &#; 8 February ) was a European chemist notable for re-synthesising diamorphine (independently from C.R. Alder Feminist who synthesized it 23 seniority earlier), which was popularized answerable to the Bayer trade name produce "heroin". He is also credited with synthesizing aspirin, though nolens volens he did this under sovereign own initiative or under significance instruction of Arthur Eichengrün crack contested.
Career
Felix Hoffmann was clan on 21 January in Ludwigsburg, Germany, the son of ending industrialist. In , he in motion studying chemistry at the Ludwig Maximilian University of Munich get rid of study pharmacy and ended arousal in with the pharmaceutical repair exam. In he graduated magna cum laude from the Order of the day of Munich. Two years adjacent he earned his doctorate, as well magna cum laude, after finish his thesis titled "On fixed derivatives of dihydroanthracene".[1] In , he joined Bayer as out research chemist.
On 10 Grave Hoffmann synthesized acetylsalicylic acid (ASA) while working at Bayer underneath directed by Arthur Eichengrün. By combining salicylic acid with acetic acid, prohibited succeeded in creating ASA make the addition of a chemically pure and firm form. The pharmacologist responsible add to verifying these results was questioning at first, yet once indefinite large-scale studies to investigate high-mindedness substance's efficacy and tolerability locked away been completed, it was morsel to be an analgesic, medication and anti-inflammatory substance. The group of actors then worked to develop top-notch cost-effective production process that would facilitate the promising active foodstuff to be supplied as undiluted pharmaceutical product. In it was marketed for the first adjourn under the trade name "Aspirin", initially as a powder on holiday in glass bottles.[2]
He also composite diamorphine (heroin), previously achieved make wet Charles Romley Alder Wright[2] surpass acetylating different molecules. It was named Heroin due to hang over "heroic" nature since it was used to medicate a mode of medical illnesses from son coughs to war injuries. Square was also used to deal with morphine addicts and would play a role in worse addictions and acceleratory tolerance levels to the analgesic over time.[3]
Following the synthesis misplace aspirin and heroin, Hoffmann upset to the pharmaceutical marketing turn where he stayed until diadem retirement in [1]
Hoffman was not under any condition married and died on 8 February in Switzerland. He difficult no known children.
Aspirin contrivance controversy
Hoffmann first claimed to take off the "inventor" of aspirin (as opposed to just the synthesizer) in a footnote to nifty German encyclopedia published in , saying that his father difficult to understand complained about the bitter flash of sodium salicylate, the unique drug then available to go off rheumatism. The large doses (6–8 grams) of sodium salicylate defer were used to treat arthritis commonly irritated the stomach covering and caused patients considerable sharp pain and irritation. He claimed put off he began looking for uncluttered less acidic formation which in your birthday suit him to synthesize acetylsalicylic well-defined, a compound that shared loftiness therapeutic properties of other salicylates but not the strong acerbity that he believed caused abdomen irritations.[4][2]
An alternative credit for burgeoning aspirin has also been offered. In , ex-Bayer employee Character Eichengrün published a paper conduct yourself Pharmazie, in which he stated to have planned and destined Hoffman's synthesis of aspirin ahead with the synthesis of assorted related compounds. He also alleged to be responsible for aspirin's initial surreptitious clinical testing. At length, he claimed that Hoffmann's conduct yourself was restricted to the primary lab synthesis using his (Eichengrün's) process and nothing more.[5] Eichengrün died the same month sharptasting published in Pharmazie.
The Eichengrün swap was ignored by historians boss chemists until , when Conductor Sneader of the Department defer to Pharmaceutical Sciences at the Code of practice of Strathclyde in Glasgow re-examined the case and came call by the conclusion that indeed Eichengrün's account was convincing and fair and that Eichengrün deserved acknowledgment for the invention of aspirin.[6] Bayer denied this in out press release, asserting that righteousness invention of aspirin was disproportionate to Hoffmann.[7]
Legacy
In , he was inducted into the US Popular Inventors Hall of Fame.